The elements to be taken into account in a complete evaluation of a method or system can be derived from the properties of the quantitative relationship between the “input” and the “output” for the system.
PARAMETER ELIMINATION BY SEQUENTIAL TESTING FREE
Effective use of a method or observation requires that we know the ways and degrees to which the data are free of error, not that we know only that the data are “accurate” or “inaccurate”. “Accurate” is frequently used to refer indiscriminately to the effect of any of these elements, or to the combined effects of all of them on the freedom from error of a system. The use of the single word “accurate” also hides the fact that a number of separate elements contribute to over-all freedom from error. The use of the word “accurate” – free of error – in referring to a scientific observation or scientific method sometimes obscures the fact that even the best methods and observations are only relatively free from error.
b, Compartment(s), Volume of Distribution, Half-Life a is used as a subscript for pharmacokinetic parameters appropriate to the distributive phase, e.g., t 1/2a, V da, etc.Ĭf. The earlier segment of a biphasic plot of log C against t (following intravenous injection of a drug) represents the “distributive phase” of a drug’s sojourn in the body. The amount of drug in the drug’s volume of distribution is equal to the concentration of the drug times the volume: A = C Special attributes of the amount are indicated by subscripts: A 0, the amount of drug in the body at “zero-time ” A B, the amount of drug in the body A U, the amount of drug recovered in the urine, etc. Please report any faulty links on the Contact Us page.Ī – B – C – D – E – F – G – H – I – K – L – M – N – P – R – S – T – U – V – ZĪn amount of drug or chemical in units of mass such as milligrams. Questions or comments should be mailed to Carol Walsh, Ph.D. Professor Emeritus and Former Chairman of Pharmacology Glossary of Terms and Symbols Used in PharmacologyĬopyright 1995-2022 by Trustees of Boston University.
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